Journal article
Effects of dexmedetomidine on kidney and brain tissue microcirculation and histology in ovine cardiopulmonary bypass: a randomised controlled trial
AH Jufar, CN May, LC Booth, RG Evans, AD Cochrane, B Marino, I Birchall, SG Hood, PR Mccall, RD Sanders, ST Yao, V Ortega-Bernal, A Skene, R Bellomo, LF Miles, YR Lankadeva
Anaesthesia | Wiley | Published : 2023
DOI: 10.1111/anae.16152
Abstract
Cardiac surgery requiring cardiopulmonary bypass is associated with postoperative acute kidney injury and neurocognitive disorders, including delirium. Intra-operative inflammation and/or impaired tissue perfusion/oxygenation are thought to be contributors to these outcomes. It has been hypothesised that these problems may be ameliorated by the highly selective α2-agonist, dexmedetomidine. We tested the effects of dexmedetomidine on renal and cerebral microcirculatory tissue perfusion, oxygenation and histology in a clinically relevant ovine model. Sixteen sheep were studied while conscious, after induction of anaesthesia and during 2 h of cardiopulmonary bypass. Eight sheep were allocated r..
View full abstractGrants
Awarded by LM and YL contributed equally to this study. This study was supported by project grants from the National Health and Medical Research Council of Australia (GNT1122455 and GNT1185777) and the National Heart Foundation of Australia (VG104674). The authors th
Awarded by National Health and Medical Research Council of Australia
Awarded by National Heart Foundation of Australia
Awarded by Australian Research Council Future Fellowship
Funding Acknowledgements
LM and YL contributed equally to this study. This study was supported by project grants from the National Health and Medical Research Council of Australia (GNT1122455 and GNT1185777) and the National Heart Foundation of Australia (VG104674). The authors thank Mr T. Dornom, Mr T. Vale and Mr Q. Nguyen for their technical assistance. We would also like to acknowledge the support of the Advanced Microscopy Facility at the Florey Institute of Neuroscience and Mental Health for training, advice and assistance in using the microscopes at the facility. SY was supported by an Australian Research Council Future Fellowship (FT170100363). YL was supported by a Future Leader Fellowship from the National Heart Foundation of Australia (NHF105666). AJ was supported by a postgraduate scholarship from Monash University. No other competing interests declared.